Research

Experimental: How do flexible circuits emerge in auditory cortical circuits?

In this project, we are interested in exploring the neural basis of flexible auditory behavior. By combining tractable rodent behavior, high-density silicon recording arrays, and novel analytical tools, we can explore when and where large ensemble activity is recruited for adaptive behavior. Using activity-dependent optogenetics we can establish causal relationships between ensemble activity patterns during different phases of learning.These experiments will yield a rich data set for exploring high-dimensional dynamics using computational models to determine whether ensembles in each learning phase evolve in their own subspace or interact in high-dimensional trajectories.

Computation: What are the network dynamics gating flexible auditory behavior?

In this project, we are interested in exploring the network dynamics that gate flexible auditory behavior. Using in vivo whole-cell recordings during behavior, we can measure how synaptic inputs are altered in auditory cortical circuits and dynamics at the single-cell input-to-output level. To gain a more mechanistic understanding of how auditory learning is gated, we use spiking recurrent neural network models to examine the population-wide mechanisms which allow for behavioral flexibility and generate new hypotheses to test experimentally.

Translation: Novel neurotechnologies for restoring perceptual flexibility

The lab also has an interest in understanding how sensory neuroprosthetic devices like cochlear implants interface with the brain. In the long term, we are also interested in developing next-generation neuroprosthetic devices capable of restoring perceptual flexibility using closed-loop feedback to remediate neurological disorders such as hearing loss.